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Brian McMillen on X: "The cause of signet ring cell change isn't completely understood. Apparently, mucosal inflammation and ischemia cause epithelial cells to slough and 'round up', resulting in signet ring-like morphology.
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Microscopy demonstrating typical signet ring cells (black arrows) with... | Download Scientific Diagram
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Image showing the signet-ring cell morphology at higher magnifications... | Download Scientific Diagram
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